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There are three different kinds of hostnames that a system might have in a failover configuration; each type maps to a type of network, as discussed previously. One is its private name. This is the name found in system configuration files, and the one that shows up if you ask the host for its name. Depending on how the network is configured, that name may or may not be resolved on the network. If your machine s private name is shirley, that does not necessarily mean that other hosts on the same network know the machine as shirley. The second kind of name is the public name. This is the name that maps to IP addresses that other systems on the network know about. In a failover configuration, this name and IP address should not map to a particular machine, but rather to the application that is requested through that name. The third kind of name is the administrative interface name. That name may or may not match the system s private name. It s probably best if it does, but it does not have to. For example, in a configuration with an administrative network, one public network, two heartbeat networks, and an NFS server, a pair of servers might use the following hostnames:

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laverne and shirley are the real hostnames. They are the names assigned to the administrative network interfaces, which means that only the system administrators will access the systems using these names. They refer to physical machines and not logical services. milwaukee-nfs is the logical hostname. It doesn t correspond precisely to one interface, but will instead be bound to the primary server s (shirley s) public network interface by default and migrate to the takeover server s (laverne s) public network link during a failover. shirley-net1 is the administrative hostname assigned to the public network on the primary server. Similarly, laverne-net1 is the administrative hostname on the secondary server. Further discussion of administrative networks can be found in the next section. shirley-hb1, shirley-hb2, laverne-hb1, and laverne-hb2 are the hostnames for the interfaces connected to the redundant heartbeat networks. (Note that some FMSs do not require IP addresses or hostnames on their heartbeat ports.)

On the other hand, an application or software package that provides multiple communication points would facilitate the development of this adapter. This is the case for certain ERP, notably of the most widespread, R3 from SAP. Indeed, SAP offers several methods for exchanging information with the modules that compose it: API (BAPIs), communication in batch mode (BTCI), communication in conversational mode (ALE), etc. However, these communication modes do not all present the same coverage or the same technical capacities (notably in terms of volume to be processed). In most cases then, with this type of software package, several adapters are required, each using a method of communication and, in certain cases, a single adapter that covers all of these methods. Further, an adapter must whenever possible allow the application to recover the description of the data that it manipulates (the metadata). This data can be used to input the dictionary where transformation rules are defined (see section 3.2.4) with the structures of events or data. For example, this could be done by having the application extract the description of the tables that it uses directly from the database.

Moral of the story: You re going to use an awful lot of hostnames and IP addresses. Make sure that you have a sufficient number of subnets available and IP address space to allocate for each server pair. Also, keep the names obvious, and use suffixes indicating what net, what kind of network, and what number the interface is on a net if required. Refer back to Key Design Principle #1 about simplicity: It counts when you re sorting through 14 network interfaces, trying to figure out why a secondary server can t send NFS replies back to clients connected through a router.

antibodies Ribozymes (ribonucleotides with catalytic activity) are also targets for directed evolution; efforts are underway to obtain ribozymes with new catalytic activities Examples of target molecules and their new/improved functions are presented in Table 81 82 RATIONAL DESIGN AND DIRECTED EVOLUTION Rational protein design (or protein engineering) implies the use of knowledge to design or improve the characteristics of a biomolecule Rational protein design is accomplished by methods such as site-directed mutagenesis and the insertion or deletion of DNA sequences to yield predictable changes in protein properties Rational methods have been used successfully to improve enzymatic stability at high temperature and toward other denaturing physical or chemical agents Rational methods are based on experimental evidence that the effect of single amino acid substitutions on protein stability can be well approximated as additive, distributed, and large independent interactions.